Is enzalutamide safe? Enzalutamide Price may cause heart problems including ischemic heart disease. Check with your doctor right away if you have chest pain or discomfort or pain or discomfort in the arms, jaw, back, or neck. Do not take other medicines unless they have been discussed with your doctor. When is the best time to take enzalutamide? You should take the tablets at the same time each day and swallow them whole with water. You can take the tablets with or without food. If you were having hormone therapy before starting enzalutamide, you will probably continue having it together with enzalutamide, even if it's stopped working so well.